Buffalo Chicken Casserole

This Buffalo Chicken Casserole is a creamy, cheesy, spicy comfort food classic that’s incredibly easy to make and packed with bold flavor. It’s the perfect weeknight dinner that comes together quickly and bakes to bubbly perfection in under an hour!

If you’re wondering what to make with leftover rotisserie chicken, this buffalo chicken pasta bake is one of my go-to recipes. It’s hearty, satisfying, and has just the right kick of heat balanced with creamy goodness. For more comforting meals, you might also enjoy a creamy chicken alfredo pasta or a classic baked ziti.

Why you’ll love it

Buffalo chicken is one of those flavor combinations that never gets old. The tangy heat from the hot sauce, paired with rich creamy Alfredo and melty cheese, creates an irresistible balance that keeps you coming back for more.

I absolutely love how this casserole transforms simple pantry ingredients into something that tastes like it came straight out of a restaurant kitchen. It’s comforting, bold, and incredibly satisfying.

What makes this recipe even better is how easy it is. You don’t need any complicated steps or fancy equipment—just cook the pasta, mix everything together, and bake. It’s perfect for busy weeknights, meal prep, or even game day gatherings.

Another reason I keep making this dish? It’s super versatile. You can easily adjust the spice level, swap cheeses, or add veggies to make it your own. Plus, it’s a fantastic way to use up leftover chicken.

And let’s not forget—the cheesy golden top layer that comes out of the oven bubbling and slightly crispy is pure comfort food heaven.

What you’ll need

Here’s everything I use to make this creamy buffalo chicken casserole:

• Penne pasta – A sturdy pasta that holds onto the sauce perfectly
• Cooked chicken – Rotisserie chicken works amazingly well for convenience and flavor
• Alfredo sauce – The creamy base that balances the heat from the buffalo sauce
• Frank’s Red Hot Original Sauce – The star ingredient that gives that signature buffalo flavor
• Blue cheese crumbles (optional) – Adds tangy depth and classic buffalo pairing
• Ranch seasoning packet – Brings a savory, herby flavor that ties everything together
• Shredded mozzarella cheese – Melts beautifully for that gooey, cheesy texture
• Chopped scallions (optional) – Adds freshness and a pop of color

Tools for this recipe

You don’t need much to make this dish, which is one of the reasons I love it so much:

• A large pot for boiling pasta
• A mixing bowl
• A baking dish (9×13 works perfectly)
• A wooden spoon or spatula

How to make Buffalo Chicken Casserole

This is a simple overview—full instructions are in the recipe card below!

Step 1: Cook the pasta

Bring a large pot of salted water to a boil and cook the penne according to package instructions until al dente. Drain and set aside.

Step 2: Prep the mixture

In a large mixing bowl, combine the cooked chicken, Alfredo sauce, buffalo sauce, ranch seasoning, and half of the mozzarella cheese. Mix until everything is well coated.

Step 3: Combine

Add the cooked pasta to the bowl and gently toss everything together until evenly mixed.

Step 4: Assemble

Transfer the mixture into a greased baking dish and spread it out evenly.

Step 5: Add toppings

Sprinkle the remaining mozzarella cheese on top. Add blue cheese crumbles if using.

Step 6: Bake

Bake in a preheated oven at 375°F (190°C) for about 20–25 minutes, or until the cheese is melted and bubbly.

Step 7: Garnish & serve

Remove from the oven and top with chopped scallions. Serve warm and enjoy!

Pro tips

• Use rotisserie chicken for maximum flavor and convenience
• Don’t overcook the pasta—it will continue cooking in the oven
• If you like extra heat, add more buffalo sauce or a pinch of chili flakes
• Let the casserole rest for 5 minutes before serving so it sets nicely
• Use freshly shredded cheese for the best melt and texture

Substitutions and variations

This recipe is super flexible, and I love experimenting with it:

• No Alfredo sauce? Use a homemade cream sauce or even cream cheese + milk
• Not a fan of blue cheese? Skip it or replace with feta
• Want it spicier? Add cayenne pepper or extra hot sauce
• Make it lighter: Use reduced-fat cheese and light Alfredo
• Add veggies: Broccoli, spinach, or bell peppers work great
• Swap pasta: Try rotini, rigatoni, or even macaroni

What to serve with Buffalo Chicken Casserole

This casserole is rich and filling, so I like to pair it with something fresh or crunchy:

• A crisp green salad with a light vinaigrette
• Garlic bread or dinner rolls
• Roasted vegetables like carrots or broccoli
• Coleslaw for a refreshing contrast

Leftovers and storage

• Store leftovers in an airtight container in the fridge for up to 3–4 days
• Reheat in the oven or microwave until warmed through
• Add a splash of milk or cream when reheating to keep it creamy
• You can freeze it, but note that the texture may change slightly due to the creamy sauce

Final thoughts

This Buffalo Chicken Casserole is one of those recipes I find myself making again and again. It’s easy, comforting, and full of bold flavor that everyone loves. Whether you’re cooking for your family, hosting friends, or just craving something cozy, this dish never disappoints.